This paper presents an integrated mathematical framework for addressing the problem of extracting meaning from uncertain and noisy data. It provides a framework that connects classical estimation theory, statistical inference, and modern machine learning, including deep learning and large-scale language models. By analyzing how techniques such as maximum likelihood estimation, Bayesian inference, and attention mechanisms deal with uncertainty, we demonstrate that many AI methods are based on common probabilistic principles. Using examples from system identification, image classification, and language generation, we demonstrate how increasingly complex models build on this foundation to address practical challenges such as overfitting, data scarcity, and interpretability. We demonstrate that maximum likelihood estimation, MAP estimation, Bayesian classification, and deep learning all represent different aspects of the common goal of inferring hidden causes from noisy or biased observations. This paper serves as a theoretical synthesis and a practical guide for students and researchers exploring the evolving landscape of machine learning.