Daily Arxiv

This is a page that curates AI-related papers published worldwide.
All content here is summarized using Google Gemini and operated on a non-profit basis.
Copyright for each paper belongs to the authors and their institutions; please make sure to credit the source when sharing.

Age-Normalized HRV Features for Non-Invasive Glucose Prediction: A Pilot Sleep-Aware Machine Learning Study

Created by
  • Haebom

Author

Md Basit Azam, Sarangthem Ibotombi Singh

Outline

This paper presents the results of a study on noninvasive blood glucose prediction using heart rate variability (HRV) during sleep. Considering age-related autonomic changes that affect conventional HRV analysis, we analyzed multimodal data, including sleep-stage ECGs, HRV features, and clinical measurements, from 43 subjects. We applied a novel technique to normalize HRV features by an age-dependent scaling factor and used Bayesian ridge regression to predict log blood glucose levels. Age-normalized HRV features achieved an R² = 0.161 (MAE = 0.182) for log blood glucose prediction, demonstrating a 25.6% improvement over unnormalized features (R² = 0.132). The most predictive features were age-normalized mean RR interval during REM sleep, age-normalized mean RR interval during deep sleep, and diastolic blood pressure. Further analysis confirmed the importance of age normalization, while sleep-stage features provided additional predictive power.

Takeaways, Limitations

Takeaways:
We show that age-normalized HRV features can improve blood glucose prediction accuracy compared to existing methods.
We suggest that sleep-stage-specific HRV analysis can provide additional predictive power.
Presenting new possibilities for noninvasive blood glucose monitoring.
Proposing a sleep awareness methodology that addresses the fundamental limitations of autonomic nervous system function assessment.
Limitations:
Because the number of study subjects was limited (43 people), validation in a larger cohort is needed.
Further research is needed for clinical application.
👍