This paper argues that a responsible, application-focused approach (RAD-AI) is necessary to achieve meaningful scientific and societal progress in artificial intelligence (AI). As AI becomes increasingly integrated into society, AI researchers must engage with the specific contexts in which it is being deployed. This includes addressing ethical and legal considerations, technical and social constraints, and public discourse. This paper proposes a three-step approach to advancing research through RAD-AI: (1) building interdisciplinary teams and human-centered research; (2) addressing context-specific methods, ethical commitments, assumptions, and metrics; and (3) testing and sustaining efficacy through phased testbeds and communities of practice. Ultimately, this paper presents a vision for the future of application-focused AI research, aiming to create new value through technically feasible methods that adapt to the contextual needs and values of the communities in which it serves.