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Early Detection of Pancreatic Cancer Using Multimodal Learning on Electronic Health Records
Created by
Haebom
Author
Mosbah Aouad, Anirudh Choudhary, Awais Farooq, Steven Nevers, Lusine Demirkhanyan, Bhrandon Harris, Suguna Pappu, Christopher Gondi, Ravishankar Iyer
Outline
This paper presents a novel multimodal approach for the early diagnosis of pancreatic ductal adenocarcinoma (PDAC). Specifically, we propose a method to detect PDAC up to 1 year before clinical diagnosis by integrating longitudinal diagnosis code histories from electronic health records (EHRs) with regularly collected laboratory measurements. We combine neural controlled differential equations to model non-stationary laboratory time series, pretrained language models and recurrent neural networks to learn diagnosis code trajectory representations, and a cross-attention mechanism to capture the interaction between the two modalities. We develop and evaluate the approach on a real-world dataset of approximately 4,700 patients, achieving significant improvements in AUC (range, 6.5% to 15.5%) over state-of-the-art methods. Furthermore, we identify a panel of diagnosis codes and laboratory tests that are associated with a high risk of PDAC, including both established and novel biomarkers. The source code is available at https://github.com/MosbahAouad/EarlyPDAC-MML .