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Large Intestine 3D Shape Refinement Using Point Diffusion Models for Digital Phantom Generation

Created by
  • Haebom

Author

Kaouther Mouheb, Mobina Ghojogh Nejad, Lavsen Dahal, Ehsan Samei, Kyle J. Lafata, W. Paul Segars, Joseph Y. Lo

Outline

This paper proposes CLAP (Conditional LAtent Point-diffusion model), a novel method for accurate 3D modeling of human organs, such as the colon, which are challenging due to their complex geometry and shape variation. CLAP enhances the 3D representation of the colon by combining geometric deep learning with a denoising diffusion model. Using point clouds sampled from segmentation masks, we learn global and local latent shape representations via hierarchical variational autoencoders, and then refine the organ shape within the latent space using two conditional diffusion models. Finally, we transform the refined point cloud into a mesh using a pretrained surface reconstruction model. Experimental results show that CLAP significantly improves shape modeling accuracy, reducing the Chamfer distance by 26% and the Hausdorff distance by 36% compared to the initial shape. This provides a robust and scalable high-fidelity organ modeling solution applicable to a variety of anatomical structures.

Takeaways, Limitations

Takeaways:
Presenting high-accuracy 3D modeling technology for complex organs, especially the large intestine.
Demonstrated performance improvement by reducing Chamfer distance and Hausdorff distance compared to existing methods.
Presenting applicability to various anatomical structures.
Potential applications in high-fidelity medical image simulation and analysis.
Limitations:
Further verification of the generalization performance of the proposed model is needed.
Further research is needed on modeling that reflects various disease states and individual differences.
Reliance on pre-trained surface reconstruction models.
Analysis of computational costs and processing times is required.
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