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PGAD: Prototype-Guided Adaptive Distillation for Multi-Modal Learning in AD Diagnosis

Created by
  • Haebom

Author

Yanfei Li, Teng Yin, Wenyi Shang, Jingyu Liu, Xi Wang, Kaiyang Zhao

Outline

To address the missing modality problem in Alzheimer's disease (AD) diagnosis, where many patients lack complete imaging data due to cost and clinical constraints, we propose a prototype-guided adaptive distillation (PGAD) framework that directly integrates incomplete multimodal data into learning. PGAD enhances the missing modality representation through prototype matching and balances learning through a dynamic sampling strategy. We validate PGAD on the ADNI dataset with various missing rates (20%, 50%, and 70%), demonstrating significant performance improvements over existing state-of-the-art approaches. Further experiments confirm the effectiveness of prototype matching and adaptive sampling, highlighting the potential of this framework for robust and scalable AD diagnosis in real-world clinical settings.

Takeaways, Limitations

Takeaways:
We present a novel framework that can effectively utilize incomplete multimodal data to improve the accuracy of Alzheimer's disease diagnosis.
Effectively exploit missing modality information through prototype matching and dynamic sampling strategies.
Contributes to improving the robustness and scalability of Alzheimer's disease diagnosis in real clinical settings.
It shows higher performance than existing methods and shows effective results even at various omission rates.
Limitations:
The performance of PGAD presented in this paper is limited to the ADNI dataset, and further research is needed to determine its generalization performance on other datasets.
Further research is needed on optimal parameter settings for prototype matching and adaptive sampling strategies.
There is a need to evaluate the robustness of PGAD to other types of missing data patterns.
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