Daily Arxiv

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Invisible Attributes, Visible Biases: Exploring Demographic Shortcuts in MRI-based Alzheimer's Disease Classification

Created by
  • Haebom

Author

Akshit Achara, Esther Puyol Anton, Alexander Hammers, Andrew P. King

Outline

This paper investigates shortcut learning and demographic bias issues in deep learning (DL) algorithms for Alzheimer's disease (AD) diagnosis using magnetic resonance imaging (MRI). First, we examine whether DL algorithms can identify race or gender in 3D brain MRI scans, thereby identifying distributional shifts based on race and gender. Next, we investigate whether training set imbalances based on race or gender degrade model performance, thereby identifying shortcut learning and bias. Finally, we conduct quantitative and qualitative analyses of feature attributions across different brain regions for both protective attributes and AD classification tasks. Using multiple datasets and DL models (ResNet and SwinTransformer), we demonstrate the presence of shortcut learning and biases based on race and gender in DL-based AD classification. This study lays the foundation for more impartial DL diagnostic tools in brain MRI.

Takeaways, Limitations

Takeaways: We empirically demonstrated the presence of racial and gender bias in deep learning models for Alzheimer's disease diagnosis based on brain MRI. This represents an important step toward developing more fair and reliable diagnostic tools. The provided code enhances the reproducibility of the study.
Limitations: This may be a result limited to a specific dataset and model. More extensive research is needed across diverse racial and gender groups. Specific solutions to mitigate bias are lacking. Further research is needed to determine how to completely eliminate shortcut learning.
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