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This study presents a novel method to reduce the acquisition time of a promising diffusion MRI glial exchange imaging model for exploring glial microstructure. Because existing protocols require long scan times, the research team developed a data-driven, optimized 8-feature subset for the Connectome 2.0 scanner using explainable artificial intelligence and a supervised recursive feature elimination strategy. This optimized protocol was validated through synthetic data and in vivo experiments and compared with existing protocols and other reduction methods. Results showed that the optimized protocol significantly reduced scan time to 14 minutes while maintaining model accuracy, maintaining accurate parameter estimation and anatomical contrast, and not affecting reproducibility. Notably, it demonstrated superior robustness, reducing the variance in water exchange time estimates by more than a factor of 2 compared to existing theory-based and heuristic reduction methods.
Takeaways, Limitations
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Takeaways:
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A dramatic reduction in scan time (14 minutes) for diffusion MRI neuroglial exchange imaging has been achieved, enhancing its applicability in neuroscience and clinical research.
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We present a generalizable methodology for acquisition protocol optimization using data-driven, explainable artificial intelligence techniques.
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We developed an optimized protocol with superior accuracy and robustness over existing theory-based and heuristic reduction methods.
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Increased the efficiency of glial cell ultrastructural analysis.
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Limitations:
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Because the methodology used in this study was specific to the Connectome 2.0 scanner, generalizability to other scanners requires further study.
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Further explanation of the biological basis for the selection of the optimized 8-feature subset may be required.
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Further research is needed to verify generalizability to diverse populations.