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AI Models for Depressive Disorder Detection and Diagnosis: A Review

Created by
  • Haebom

Author

Dorsa Macky Aleagha, Payam Zohari, Mostafa Haghir Chehreghani

Outline

This paper explores the potential of artificial intelligence (AI) to develop objective, scalable, and timely diagnostic tools for major depressive disorder (MDD), a leading cause of disability worldwide. Given that the diagnosis of this disorder still relies heavily on subjective clinical assessments, this paper explores the potential of AI-powered approaches to detect and diagnose depression. Based on a systematic review of 55 key studies, we conduct a comprehensive survey of state-of-the-art AI methods for depression detection and diagnosis. We introduce a novel hierarchical taxonomy that structures the field by diagnostic versus predictive approaches, data modality (text, speech, neuroimaging, multimodal), and computational model class (e.g., graph neural networks, large-scale language models, hybrid approaches). Our in-depth analysis reveals three key trends: the rise of graph neural networks for brain connectivity modeling, the rise of large-scale language models for language and conversational data, and a growing focus on multimodal convergence, explainability, and algorithmic fairness. Along with methodological insights, we provide an overview of key public datasets and standard evaluation metrics as a practical guide for researchers. By synthesizing current advances and highlighting open challenges, this paper offers a comprehensive roadmap for future innovations in computational psychiatry.

Takeaways, Limitations

Takeaways:
Presenting the possibility of developing an AI-based depression diagnosis and prediction tool and providing an analysis of the current status.
Provides insights into the application of AI technologies such as graph neural networks, large-scale language models, and multimodal fusion to depression diagnosis.
Introducing key public datasets and evaluation metrics in the field of depression diagnosis.
Suggesting future research directions in the field of computational psychiatry.
Limitations:
Lack of clear explanation of the selection criteria and potential bias of the 55 studies presented in the paper.
Limited analysis of the performance comparison and generalizability of various AI models.
Highlights the need for further research on algorithmic fairness and explainability.
The need for further validation and research for application in actual clinical settings.
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