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Adaptive Learning Strategies for Mitotic Figure Classification in MIDOG2025 Challenge

Created by
  • Haebom

Author

Biwen Meng, Xi Long, Jingxin Liu

Outline

Atypical mitotic figures (AMFs) are a clinically important indicator of abnormal cell division, but their reliable detection is challenging due to morphological ambiguity and scanner variability. In this study, we investigated three variants of the pathology-based model UNI2 applied to the MIDOG2025 Track 2 challenge: (1) LoRA + UNI2, (2) VPT + UNI2 + Vahadane Normalizer, and (3) VPT + UNI2 + GRL + Stain TTA. We found that integrating visual prompt tuning (VPT) with stain normalization improved generalization performance. The addition of test-time augmentation (TTA) using Vahadane and Macenko stain normalization achieved the highest robustness. The final submission achieved a balanced accuracy of 0.8837 and an ROC-AUC of 0.9513, placing it among the top 10 teams on the preliminary leaderboard. These results suggest that combining prompt-based adaptation with stain-normalized TTA is a promising strategy for classifying atypical mitoses under a variety of imaging conditions.

Takeaways, Limitations

Takeaways: We demonstrate that a combined approach of visual prompt tuning (VPT), dye normalization (Vahadane, Macenko), and test time augmentation (TTA) effectively improves performance and ensures robustness in atypical mitotic classification. Achieved top rankings in the MIDOG2025 Track 2 challenge.
Limitations: This study presents results on a specific dataset (MIDOG2025 Track 2). Further research is needed to determine generalization performance on other datasets or in clinical settings. Further research is needed to optimize the dye normalization technique used and to compare it with other prompt tuning techniques.
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