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LLM - Powered Prediction of Hyperglycemia and Discovery of Behavioral Treatment Pathways from Wearables and Diet

Created by
  • Haebom

Author

Abdullah Mamun, Asiful Arefeen, Susan B. Racette, Dorothy D. Sears, Corrie M. Whisner, Matthew P. Buman, Hassan Ghasemzadeh

Outline

In this paper, we propose a method to predict postprandial AUC and hyperglycemia using an explainable machine learning model called GlucoLens. GlucoLens utilizes data from various modalities such as wearable sensor data (activity level, blood glucose), meal records, and work logs, and integrates large-scale language models and trainable machine learning models. It was developed and evaluated based on data from a 5-week clinical trial (10 adults), and achieved a normalized root mean square error (NRMSE) of 0.123 at the optimal setting, which is 16% higher than the existing models. In addition, it recorded 73.3% accuracy and F1 score of 0.716 for predicting hyperglycemia, and suggests treatment options for preventing hyperglycemia through various counterfactual explanations.

Takeaways, Limitations

Takeaways:
Suggests the possibility of developing a personalized postprandial blood sugar management system using wearable sensor data and machine learning.
Increased reliability of prediction results and improved user understanding through explainable AI models.
Possible to provide personalized treatment strategies for predicting and preventing hyperglycemia.
Improving prediction performance by integrating data from various modalities.
Limitations:
Developed based on data from a small clinical trial (10 adults), further validation of generalizability is needed.
Lack of evaluation of model performance across diverse populations and situations.
Further research is needed on the model's stability and predictive accuracy over long periods of time.
High dependence on wearable sensor adoption rate and data quality.
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