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Robust Multimodal Learning for Ophthalmic Disease Grading via Disentangled Representation

Created by
  • Haebom

Author

Xinkun Wang, Yifang Wang, Senwei Liang, Feilong Tang, Chengzhi Liu, Ming Hu, Chao Hu, Junjun He, Zongyuan Ge, Imran Razzak

Outline

This paper emphasizes the importance of utilizing multimodal data in ophthalmic disease diagnosis, and addresses the challenges posed by the lack of multimodal data and data privacy issues in real-world medical settings. In terms of Limitations of existing deep learning methods, we point out the difficulties in extracting unique features due to redundant latent space representations caused by redundant information in complex modalities and redundant representations across modalities. To address these issues, we propose Essence-Point and Disentangle Representation Learning (EDRL) strategies. EDRL is an end-to-end framework that integrates a self-distillation mechanism to enhance feature selection and disentanglement, enabling more robust multimodal learning. The Essence-Point Representation Learning module selects discriminative features that enhance disease grade prediction performance, and the Disentangled Representation Learning module separates multimodal data into modality common and unique representations to reduce feature entanglement and improve the robustness and interpretability of ophthalmic disease diagnosis. Experimental results on multi-modal ophthalmic datasets demonstrate that the EDRL strategy significantly outperforms existing state-of-the-art methods.

Takeaways, Limitations

Takeaways:
A novel deep learning strategy (EDRL) is presented to address the problem of limited availability of multimodal data.
Effective feature selection and disentanglement via magnetic distillation mechanism
Improving the accuracy and interpretability of ophthalmic disease diagnosis
Improved performance compared to existing state-of-the-art methods
Limitations:
Further research is needed on the generalization performance of the proposed method.
Additional experiments are needed on various ophthalmic diseases and datasets.
Additional validation needed for application in real clinical settings
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