KnoVo is an intelligent framework designed to quantify and analyze the evolution of research novelty in the scientific literature. Going beyond traditional citation analysis, KnoVo determines the novelty of a paper relative to previous and subsequent work within a multi-layer citation network. Based on the abstract of the target paper, KnoVo dynamically extracts comparative dimensions (e.g., methodology, application, dataset) using a large-scale language model (LLM). It then compares the target paper to related publications along the same extracted dimensions. This comparative analysis, inspired by tournament selection, yields a quantitative novelty score that reflects the relative improvement, equivalence, or inferiority of the target paper in a particular dimension. By aggregating these scores and visualizing their progress through dynamic evolution graphs and comparative radar charts, KnoVo enables researchers to assess originality and identify similar work, as well as track the evolution of knowledge along specific research dimensions, uncover research gaps, and explore interdisciplinary connections. In this paper, we demonstrate these capabilities through a detailed analysis of 20 different papers from multiple scientific fields and report the performance of various open-source LLMs within the KnoVo framework.