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Evaluating Detection Thresholds: The Impact of False Positives and Negatives on Super-Resolution Ultrasound Localization Microscopy

Created by
  • Haebom

Author

Sepideh K. Gharamaleki, Brandon Helfield, Hassan Rivaz

Outline

Ultrasound imaging using ultrasonic microscopy (ULM) provides high-resolution images of microvascular structures, but image quality relies heavily on accurate detection of microbubbles (MBs). This study systematically adds controlled detection errors (false positives and false negatives) to simulated data to investigate the impact of false positives and false negatives on ULM image quality. While both false positive and false negative rates have similar effects on the Peak Signal-to-Noise Ratio (PSNR), increasing the false positive rate from 0% to 20% decreases the Structural Similarity Index (SSIM) by 7%, while the same increase in the false negative rate significantly reduces it by approximately 45%. Furthermore, high-density MB regions are more robust to detection errors, while low-density regions are more sensitive, demonstrating the need for a robust MB detection framework for enhancing super-resolution images.

Takeaways, Limitations

Takeaways:
We quantitatively analyzed the impact of false positives and false negatives on ULM image quality, highlighting the importance of improving MB detection algorithms.
We found that false negatives had a greater impact on ULM image quality degradation than false positives.
Since the impact of detection error varies depending on MB density, it suggests the need to develop an adaptive detection algorithm that takes MB density into account.
Limitations:
Since we used simulated data, validation against real data is required.
Further investigation is needed to determine generalizability across different ultrasound systems and settings.
There is a lack of suggestions for optimization strategies for setting specific parameters of the MB detection algorithm (e.g., detection threshold).
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