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BD-Oligo [Cataolg # P038]
■ Chemical structure & Information
BD-Oligo demonstrates a dynamic oligomer-monitoring ability during Aβ peptide fibrillogenesis, as Aβ was induced to form oligomers and eventually fibrils over time. More importantly, BD-Oligo also shows BBB penetration with capabilities of staining Aβ oligomers in vivo.
■ Cell Image
Ex vivo binding of BD-Oligo in 18 month old AD mouse brains. a, b and c show fluorescence in the APP/PS1 mouse brain injected with BD-Oligo using the channel for 6E10/4G8 labeling, BD-Oligo labeling and the merged image, respectively. BD-Oligo fluorescence was present in the brain 24 h after an I.P. injection of BD-Oligo (see b), which co-localized with the Aβ labeling (see c). Arrows indicate plaques with co-localization. d, e and f show fluorescence in the APP/PS1 mouse brain injected saline alone using the channel for 6E10/4G8 labeling, BD-Oligo labeling and the merged image, respectively. There are no plaques seen in the BD-Oligo channel in the control saline injected mice, indicating the specificity of the BD-Oligo oligomer labeling. Scale bar, 100µm.
■ Related probes: CDnir7
■ Known Property
Ab oligomer probe
■ Application
Immunofluorescence
■ Cell selectivity mechanism
unknown
Ab oligomer probe
■ Application
Immunofluorescence
■ Cell selectivity mechanism
unknown
■ Known Property
Ab oligomer probe
■ Application
Immunofluorescence
■ Cell selectivity mechanism
unknown
Ab oligomer probe
■ Application
Immunofluorescence
■ Cell selectivity mechanism
unknown
■ Reference
1.
A chemical fluorescent probe for the detection of Aß oligomers, Teoh, C. L.; Su, D. D.; Sahu, S.; Yun, S. W.; Drummond, E.; Prelli, F.; Lim, S.; Cho, S.; Ham, S.; Wisniewski, T.; Chang, Y. T. J. Am. Chem. Soc., 2015, available online
■ ORDER
International
USD 350 + VAT (10%) + Fedex delivery charge
In Korea
KRW 450,000 + VAT (10%)
100 nmol (dried form: equivalent to 1 mM / 100 µL)
■ Storage
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C
■ General Use Guide
•
More than 1/100 dilution of 10mM of DMSO stock solution is essential
•
For biomedical use to avoid DMSO concentration higher than 1%.
•
Working concentrations for specific applications should be determined by the investigator.
•
It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
precipitated out from buffer solution.
precipitated out from buffer solution.
■ Data sheet PDF file
BD-Oligo data sheet v0.2.pdf715.34KB