A library of fluorescent styryl dyes (320 compounds) was prepared by solid-phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10, showed promise as brain-imaging agents
■ Cell Image
Labeling of amyloid deposits in a slice of mouse brain with 2E10 (green, indicated by arrows). c) Confocal microscopy image of amyloid deposits labeled with 2E10 (green) and ThS (blue); note that 2E10 preferentially labels the core of deposits Labeling of amyloid deposits.
Solid phase synthesis of styryl dye library and its application to amyloid sensors, Li, Q.; Lee, J. S.; Ha, C.; Park, C. B.; Yang G.; Gan, W. B.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl., 2004, 43, 6331-6335.
