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Alzheimer's / Amyloid Probes

BD-Oligo [Cataolg # P038]

BD-Tau [Catalog # P039]

■ Chemical structure & Information
BD-tau, a BODIPY-based fluorescence sensor detects pathological tau aggregates in live cells. As a fluorescence turn-on sensor, the quantum yield of BD-tau increased 3.8-fold upon binding to tau aggregates in vitro. β-sheet protein panel assay indicates that BD-tau also responds to other β-sheet protein aggregates such as amyloid plaques and insulin aggregates. However, compared with other conventional tau probes, BD-tau has superior selectivity to tau aggregates over amyloid plaques or insulin aggregates. As a cell-permeable imaging probe, BD-tau selectively labeled pathological tau aggregates in live hippocampal neurons.
■ Cell Image
BD-tau labels tau aggregates in brain slices of a tau transgenic mouse model. The representative images of brain tissue stained with BD-tau and the anti-tau PHF antibody. Nuclei were counterstained with Hoechst. Scale bar = 100 mm.
Related probes: BD-Oligo, 2C40, 2E10
Known Property
Tau probe
Application
Immunofluorescence
Cell selectivity mechanism
unknown
Reference
1.
Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells, Lim, S.; Haque, M. M.; Su, D.; Kim, D.; Lee, J. S.; Chang, Y. T.; Kim, Y. K. Chem. Commun. 2017, 53, 1607-1610.

ORDER
International
USD 350 + VAT (10%) + Fedex delivery charge
In Korea
KRW 450,000 + VAT (10%)
100 nmol (dried form: equvalent to 1 mM / 100 µL)

Storage
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

General Use Guide
More than 1/100 dilution of 10mM of DMSO stock solution is essential
For biomedical use to avoid DMSO concentration higher than 1%.
Working concentrations for specific applications should be determined by the investigator.
It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
precipitated out from buffer solution.
Data sheet PDF file
BD-Tau data sheet v0.2.pdf392KB
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