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Alzheimer's / Amyloid Probes

BD-Oligo [Cataolg # P038]
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🔬PHOENIX FLUOR

BD-Oligo [Cataolg # P038]

■ Chemical structure & Information
BD-Oligo demonstrates a dynamic oligomer-monitoring ability during Aβ peptide fibrillogenesis, as Aβ was induced to form oligomers and eventually fibrils over time. More importantly, BD-Oligo also shows BBB penetration with capabilities of staining Aβ oligomers in vivo.
■ Cell Image
Ex vivo binding of BD-Oligo in 18 month old AD mouse brains. a, b and c show fluorescence in the APP/PS1 mouse brain injected with BD-Oligo using the channel for 6E10/4G8 labeling, BD-Oligo labeling and the merged image, respectively. BD-Oligo fluorescence was present in the brain 24 h after an I.P. injection of BD-Oligo (see b), which co-localized with the Aβ labeling (see c). Arrows indicate plaques with co-localization. d, e and f show fluorescence in the APP/PS1 mouse brain injected saline alone using the channel for 6E10/4G8 labeling, BD-Oligo labeling and the merged image, respectively. There are no plaques seen in the BD-Oligo channel in the control saline injected mice, indicating the specificity of the BD-Oligo oligomer labeling. Scale bar, 100µm.
Related probes: CDnir7Known Property
Ab oligomer probe
Application
Immunofluorescence
Cell selectivity mechanism
unknown
Known Property
Ab oligomer probe
Application
Immunofluorescence
Cell selectivity mechanism
unknown
Reference
1.
A chemical fluorescent probe for the detection of Aß oligomers, Teoh, C. L.; Su, D. D.; Sahu, S.; Yun, S. W.; Drummond, E.; Prelli, F.; Lim, S.; Cho, S.; Ham, S.; Wisniewski, T.; Chang, Y. T. J. Am. Chem. Soc., 2015, available online

ORDER
International
USD 350 + VAT (10%) + Fedex delivery charge
In Korea
KRW 450,000 + VAT (10%)
100 nmol (dried form: equvalent to 1 mM / 100 µL)

Storage
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

General Use Guide
More than 1/100 dilution of 10mM of DMSO stock solution is essential
For biomedical use to avoid DMSO concentration higher than 1%.
Working concentrations for specific applications should be determined by the investigator.
It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
precipitated out from buffer solution.
Data sheet PDF file
BD-Oligo data sheet v0.2.pdf733KB
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