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Alzheimer's / Amyloid Probes

BD-Oligo [Cataolg # P038]
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🔬PHOENIX FLUOR

2E10 [Catalog # P041]

■ Chemical structure & Information
A library of fluorescent styryl dyes (320 compounds) was prepared by solid-phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10, showed promise as brain-imaging agents
■ Cell Image
Labeling of amyloid deposits in a slice of mouse brain with 2E10 (green, indicated by arrows). c) Confocal microscopy image of amyloid deposits labeled with 2E10 (green) and ThS (blue); note that 2E10 preferentially labels the core of deposits Labeling of amyloid deposits.
Related probes: 2C40, BD-Oligo, BD-Tau
Known Property
Amyloid sensor
Application
Immunofluorescence
Cell selectivity mechanism
unknown
Reference
1.
Solid phase synthesis of styryl dye library and its application to amyloid sensors, Li, Q.; Lee, J. S.; Ha, C.; Park, C. B.; Yang G.; Gan, W. B.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl., 2004, 43, 6331-6335.

ORDER
International
USD 350 + VAT (10%) + Fedex delivery charge
In Korea
KRW 450,000 + VAT (10%)
100 nmol (dried form: equvalent to 1 mM / 100 µL)

Storage
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

General Use Guide
More than 1/100 dilution of 10mM of DMSO stock solution is essential
For biomedical use to avoid DMSO concentration higher than 1%.
Working concentrations for specific applications should be determined by the investigator.
It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
precipitated out from buffer solution.
Data sheet PDf file
2E10 data sheet v0.2.pdf443KB
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