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Alpha-cell probes

GY (Glucagon Yellow) [Catalog # P024]
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🔬PHOENIX FLUOR

GY (Glucagon Yellow) [Catalog # P024]

■ Chemical structure & Information
Glucagon yellow is a pancreatic alpha cell selective probe over beta cell. Glucagon yellow showed dose dependent fluorescence increase upon treatment of glucagon with slight red shift. In pancreatic tissue, Glucagon yellow showed a good correlation with glucagon antibody, but low correlation with insulin antibody
■ Cell Image
Fluorescence colocalization images of Glucagon Yellow in pancreas tissue. Fluorescence microscope images of Glucagon Yellow (a: TRITC channel), glucagon antibody (b: Cy5 channel), insulin antibody (f: Cy5 channel) and merged images (c for a plus b, g for e plus f). Colocalization scatter plot (d: Pearson’s coefficient 0.950, h: Pearson’s coefficient 0.681). Scale bar 20 µm.
Related probes: TP-alpha
Known Property
pancreatic alpha cell
Application
Immunofluorescence
Cell selectivity mechanism
POLD (glucagon)
Reference
1.
Synthesis of a bodipy library and its application to the development of live cell glucagon imaging probe, Lee, J. S.; Kang, N. Y.; Kim, Y. K.; Samanta, A.; Feng, S.; Kim, H. K.; Vendrell, M.; Park, J. H.; Chang, Y. T.* J. Am. Chem. Soc. 2009, 131, 10077-10082.\

ORDER
International
USD 350 + VAT (10%) + Fedex delivery charge
In Korea
KRW 450,000 + VAT (10%)
100 nmol (dried form: equvalent to 1 mM / 100 µL)

Storage
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

General Use Guide
More than 1/100 dilution of 10mM of DMSO stock solution is essential
For biomedical use to avoid DMSO concentration higher than 1%.
Working concentrations for specific applications should be determined by the investigator.
It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
precipitated out from buffer solution.
Data sheet PDf file
Glucagon Yellow data sheet v0.2.pdf374KB
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