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Elastin probe

ElaNIR [Catalog # P034]

■ Chemical structure & Information
ElaNIR showed selective binding for elastin, such as those in the aorta, lungs, and skin. ElaNIR also allowed visualization and quantification of elastin levels in young and old mice, which reflect age-dependent changes of elastin in vivo. This makes ElaNIR a unique chemical tool for monitoring changes of elastin in tissue or animal models and provides new opportunities to study the effects of chemical compounds on elastin levels in biological processes.
■ Cell Image
ElaNIR Enables Ex Vivo Detection of Elastin Cryosections were prepared from organs including the lungs (A), skin (B), and urinary bladder (C). ElaNIR signal was detected in the NIR channel (left panels). Consecutive sections were fixed with 4% paraformaldehyde, and IHC was performed with an anti-elastin antibody co-stained with Hoechst. Merged images are shown in the right panels. White arrows show elastin fibers. Scale bars, 100 μm.
■ Known Property
Elastin NIR probe
■ Application
Immunofluorescence, Ex vivo mouse imaging, In vivo imaging
■ Cell selectivity mechanism
POLD (Elastin)
■ Reference
1.
Seeing Elastin: A Near-Infrared Zwitterionic Fluorescent Probe for In Vivo Elastin Imaging: Su, D.; Teoh, C. L.; Park, S. J.; Kim, J. J.; Samanta, A.; Bi, R.; Danish, U. S.; Olivo, M.; Piantino, M.; Louis, F.; Matsusaki, M.; Kim, S. S.; Bae, M. A.; Chang, Y. T.* Chem 2018, 4, 1128-1138.

■ ORDER
International
USD 350 + VAT (10%) + Fedex delivery charge
In Korea
KRW 450,000 + VAT (10%)
100 nmol (dried form: equvalent to 1 mM / 100 µL)

■ Storage
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

■ General Use Guide
•
More than 1/100 dilution of 10mM of DMSO stock solution is essential
•
For biomedical use to avoid DMSO concentration higher than 1%.
•
Working concentrations for specific applications should be determined by the investigator.
•
It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
precipitated out from buffer solution.
■ Data sheet PDF file
ElaNIR data sheet v0.2.pdf957.30KB
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