# JC-D8 [Catalog # P036]

**■ Chemical structure & Information**

![Image](https://upload.cafenono.com/image/slashpagePost/20250919/101939_0mOtQIWGLDI8n2ay7v?q=80&s=1280x180&t=outside&f=webp)

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/220104_U5zly4tZEqjyXkmHBU?q=80&s=1280x180&t=outside&f=webp)

JC-D7/** JC-D8 **demonstrate high selectivity for the labeling of polyP that was not sensitive to a number of ubiquitous organic polyphosphates, notably RNA. Use of these probes allowed us to demonstrate the real time detection of polyP release from lysosomes in live cells.

**■ Cell Image**

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/220125_uM3KhMKVgR0abzfmMB?q=80&s=1280x180&t=outside&f=webp)

Mitochondrially targeted GFP-labeled exopolyphosphatase (mgPPX) overexpression leads to increase activity of the enzyme and therefore to a decreased levels of polyphosphate in GFP-positive mitochondria. (B, inset) colocalization profile taken along the arrow showing that GFP and **JC-D8** signal do not significantly overlap.

■ **Known Property**
Poly phosphate probe
■ **Application**
Live imaging, Immunofluorescence
■ **Cell selectivity mechanism**
unknown

■ **Reference**

1. **In Situ Investigation of Mammalian Inorganic Polyphosphate Localization Using Novel Selective Fluorescent Probes JC-D7 and JC-D8**, Angelova, P. R.; Agrawalla, B. K.; Elustondo, P. A.; Gordon, J.; Shiba, T.; Abramov, A. Y.; Chang, Y. T._; Pavlov, E. V._ ACS Chem Biol. 2014, 9, 2101-2110.

■ **ORDER**

**International**

**USD 350 + VAT (10%) + Fedex delivery charge**

**In Korea**

**KRW 450,000 + VAT (10%)**

**100 nmol** (dried form: equivalent to 1 mM / 100 µL)

[order@senprobe.com](mailto:order@senprobe.com)

■ **Storage**
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

■ **General Use Guide**

- More than 1/100 dilution of 10mM of DMSO stock solution is essential

-  For biomedical use to avoid DMSO concentration higher than 1%.

- Working concentrations for specific applications should be determined by the investigator.

- It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
- precipitated out from buffer solution.

■ **Data sheet PDF file**

JC-D8 data sheet v0.2.pdf

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