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TiNIR [Catalog # P030]
■ Chemical structure & Information
The long wavelength of TiNIR allowed the in vivo imaging of tumor in mouse model both is fluorescence and photoacoustic imaging. The affinity of TiNIR to target proteins were monitored by fluorescence and the bound protein was identified as heme oxygenase 2 (HMOX2). TIC maintain high level of reactive oxygen species (ROS) in the cell, and HMOX2 seem to detoxify cells by removing intracellular ROS.
■ Cell Image
Discovery of the NIR fluorescence probe for human lung TIC. (A) Fluorescence images show 32A, hLuEpi, TS10, and TS32 cells after being stained with TiNIR (100 nM) and DAPI (1 μg/mL) for 40 min, 37 °C. (B) Flow cytometry analyzed fluorescence intensity of 32A, hLuEpi, TS10, and TS32 cells after being stained with TiNIR (10 nM, 40 min, RT).
■ Related probes: TiY
■ Known Property
Tumor Initiating Cell (TIC) probe.
■ Application
Immunofluorescence and therapeutic treatment for TIC in animal model
■ Cell selectivity mechanism
POLD (heme oxygenase 2: HMOX2)
Tumor Initiating Cell (TIC) probe.
■ Application
Immunofluorescence and therapeutic treatment for TIC in animal model
■ Cell selectivity mechanism
POLD (heme oxygenase 2: HMOX2)
■ Reference
1.
A NIR probe tracks and treats lung tumor initiating cells by targeting HMOX2, Kim, J. J.; Lee, Y. A.; Su, D.; Lee, J.; Park, S. J.; Kim, B.; Lee, J. H. J.; Liu, X.; Kim, S. S.; Bae, M. A.; Lee, J. S.; Hong, S. C.; Wang, L.; Samanta, A.; Kwon, H. Y.; Choi, S. Y.; Kim, J. Y.; Yu, Y. H.; Ha, H. H.; Wang, Z.; Tam, W. L.; Lim, B.; Kang, N. Y.; Chang, Y. T. J. Am. Chem. Soc. 2019, 141, 14673-14686.
■ ORDER
International
USD 350 + VAT (10%) + Fedex delivery charge
In Korea
KRW 450,000 + VAT (10%)
100 nmol (dried form: equvalent to 1 mM / 100 µL)
■ Storage
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C
■ General Use Guide
•
More than 1/100 dilution of 10mM of DMSO stock solution is essential
•
For biomedical use to avoid DMSO concentration higher than 1%.
•
Working concentrations for specific applications should be determined by the investigator.
•
It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
precipitated out from buffer solution.
precipitated out from buffer solution.
■ Data sheet PDF file
TiNIR data sheet v0.2.pdf707KB