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TIC Probes

TiY [Catalog # P028]
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🔬PHOENIX FLUOR

TiY [Catalog # P028]

■ Chemical structure & Information
The chloroacetyl motif of TiY facilitated the binding target protein from TS32 cells, elucidating vimentin as TiY’s target. Vimentin is an intermediate filament and EMT (Epithelial-mesenchymal transition) marker. TiY shows the inhibitor function against vimentin, and has higher affinity to tetramer comparing to monomer vimentin. At high dose, TiY suppresses the tumor sphere growth of TIC, without much effect to differentiated cancer cells or normal epithelial cells.
■ Cell Image
Discovery of a fluorescent probe for lung TICs (A) S-cell-selective staining by TiY (B) Flow cytometry quadrant dot plot of 32A and TS32 cells after dual staining with TiY and CD166.
Related probes: TiNIR
Known Property
Tumor Initiating Cell (TIC) probe.
Application
Immunofluorescence and therapeutic treatment for TIC
Cell selectivity mechanism
POLD (heme oxygenase 2: HMOX2)
Reference
1.
Identification of Tumor Initiating Cells by a Small Molecule Fluorescent Probe through Vimentin as the Biomarker, Lee, Y. A.; Kim, J. J.; Lee, J.; Lee, J. H. J.; Sahu, S.; Kwon, H. Y.; Park, S. J.; Jang, S. Y.; Lee, J. S.; Wang, Z.; Tam, W. L.; Lim, B.; Kang, N. Y.; Chang, Y. T. Angew. Chem. Int. Ed. Engl. 2018, 57, 2851-2854.

ORDER
International
USD 350 + VAT (10%) + Fedex delivery charge
In Korea
KRW 450,000 + VAT (10%)
100 nmol (dried form: equvalent to 1 mM / 100 µL)

Storage
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

General Use Guide
More than 1/100 dilution of 10mM of DMSO stock solution is essential
For biomedical use to avoid DMSO concentration higher than 1%.
Working concentrations for specific applications should be determined by the investigator.
It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
precipitated out from buffer solution.
Data sheet PDF file
TiY data sheet v0.2.pdf651KB
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