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Microglia cell probes

CDr10a [Catalog # P010a]
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🔬PHOENIX FLUOR

CDr20 [Catalog # P020]

■ Chemical structure & Information
CDr20 works both in vitro cell culture and on brain slice. In mouse embryo, CDr20 penetrated into brain tissue and live microglia was fluorescently stained. Through iv injection, CDr20 was introduced to Alzheimer mouse brain and the microglia could be in situ imaged by two photon fluorescence microscope.
■ Cell Image
Identification of CDr20 as a microglia-specific fluorescent probe. A) Left: Experimental setup. Right: Chemical structure of CDr20 with the structure–activity relationships. B) Densitometry of non-stained or CDr20-stainedCsf1r–EGFP brain cells. C) Superimposed images of CDr20 live-cell labeling and the indicated immunolabeling in primary cultured glial cells. Scale bars=100mm.
Related probes: CDr10
Known Property
microglia selective probe
Application
Immunofluorescence
Cell selectivity mechanism
MOLD (Ugt1a7c)
Reference
1.
Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate, Kim, B.; Fukuda, M.; Lee, J. Y.; Su, D.; Sanu, S.; Silvin, A.; Khoo, A. T. T.; Kwon, T.; Liu, X.; Chi, W.; Liu, X.; Choi, S.; Wan, D. S. Y.; Park, S. J.; Kim, J. S.; Ginhoux, F.; Je, H. S.; Chang, Y. T. Angew. Chem. Int. Ed. Engl. 2019, 58, 7972-7976.

ORDER
International
USD 350 + VAT (10%) + Fedex delivery charge
In Korea
KRW 450,000 + VAT (10%)
100 nmol (dried form: equvalent to 1 mM / 100 µL)

Storage
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

General Use Guide
More than 1/100 dilution of 10mM of DMSO stock solution is essential
For biomedical use to avoid DMSO concentration higher than 1%.
Working concentrations for specific applications should be determined by the investigator.
It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
precipitated out from buffer solution.
■ Data sheet PDF file
CDr20 data sheet v0.2.pdf434KB
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