CDr20 [Catalog # P020]

Fri, 17 Jan 2025 14:08:19 GMT

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/225452_fM1klHW1BVyZGv6mZD?q=80&s=1280x180&t=outside&f=webp)

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/225531_lUU7Ehsq9CdtOwWypd?q=80&s=1280x180&t=outside&f=webp)

**CDr20** works both in vitro cell culture and on brain slice. In mouse embryo, **CDr20** penetrated into brain tissue and live microglia was fluorescently stained. Through iv injection, **CDr20** was introduced to Alzheimer mouse brain and the microglia could be in situ imaged by two photon fluorescence microscope.

**■ Cell Image**

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/225604_uQJENlSBhyGs1VnuAp?q=80&s=1280x180&t=outside&f=webp)

Identification of **CDr20** as a microglia-specific fluorescent probe. A) Left: Experimental setup. Right: Chemical structure of CDr20 with the structure–activity relationships. B) Densitometry of non-stained or CDr20-stainedCsf1r–EGFP brain cells. C) Superimposed images of CDr20 live-cell labeling and the indicated immunolabeling in primary cultured glial cells. Scale bars=100mm.

■ **Related probes**: CDr10

■ **Known Property**
microglia selective probe
■ **Application**
Immunofluorescence
■ **Cell selectivity mechanism**
MOLD (Ugt1a7c)

■ **Reference**

1. **Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate**_, Kim, B.; Fukuda, M.; Lee, J. Y.; Su, D.; Sanu, S.; Silvin, A.; Khoo, A. T. T.; Kwon, T.; Liu, X.; Chi, W.; Liu, X.; Choi, S.; Wan, D. S. Y.; Park, S. J.; Kim, J. S.; Ginhoux, F.; Je, H. S.; Chang, Y. T._ Angew. Chem. Int. Ed. Engl. 2019, 58, 7972-7976.

■ **ORDER**

**International**

**USD 350 + VAT (10%) + Fedex delivery charge**

**In Korea**

**KRW 450,000 + VAT (10%)**

**100 nmol** (dried form: equivalent to 1 mM / 100 µL)

[order@senprobe.com](mailto:order@senprobe.com)

■ **Storage**
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

■ **General Use Guide**

- More than 1/100 dilution of 10mM of DMSO stock solution is essential

- For biomedical use to avoid DMSO concentration higher than 1%.

- Working concentrations for specific applications should be determined by the investigator.

- It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
- precipitated out from buffer solution.

**■ Data sheet PDF file**

CDr20 data sheet v0.2.pdf