CDg18 [Catalog # P018]

Mon, 20 Jan 2025 12:06:50 GMT

**■ Chemical structure & Information**

![Image](https://upload.cafenono.com/image/slashpagePost/20250919/101343_hW1G4tUVPgzVKBeqiS?q=80&s=1280x180&t=outside&f=webp)

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/222703_hA8xqLVuuXEH2mS5dc?q=80&s=1280x180&t=outside&f=webp)

M2 selective probe **CDg18** with a novel mechanism of Gating-Oriented Live-cell Distinction through M2 favored fatty acid transporters. **CDg18** visualized the progressive phenotypic change of M2 towards M1 using a resveratrol analogue HS-1793 as a reprogramming effector. Combined together with M1 probe CDr17, the diminishing M2 character and emerging M1 markers could be simultaneously monitored in real time through the multi-color changes during the macrophage reprogramming.

**■ Cell Image**

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/222642_UuGi4OlGmYR00Gg57i?q=80&s=1280x180&t=outside&f=webp)

Development of Development of M2 macrophage selective probe, **CDg18** a. The M2 macrophage selectivity of CDg18 through the image-based screening. b. The merged histogram image of the CDg18 treated M0 (red), M1 (blue), M2 (orange) macrophage cells. The graph shows the CDg18 intensity on each type of macrophage by flowcytometry. c. Colocalization image with Nile Red and CDg18. The images were taken using operetta CLS with x 20 objective lens. Scale bar: 20 μm.

■ **Known Property**
M2 macrophage probe
■ **Application**
Immunofluorescence
■ **Cell selectivity mechanism**
GOLD

■ **Reference**

1. **Development of a Fluorescent Probe for M2 Macrophages via Gating-Oriented Live-Cell Distinction**, Cho, H.; Kwon, H. Y.; Lee, S. H.; Lee, H. G.; Kang, N. Y._; Chang, Y. T._ J. Am. Chem. Soc. 2023, 145, 2951-2957. (published on 2023 2 8) [https://doi.org/10.1021/jacs.2c11393](https://doi.org/10.1021/jacs.2c11393)

■ **ORDER**

**International Sales only ****※Not available for Sale in Korea**

**USD 350 + VAT (10%) + Fedex delivery charge**

**100 nmol** (dried form: equivalent to 1 mM / 100 µL)

**Inquire Now:**** ****[order@senprobe.com](mailto:order@senprobe.com)**

■ **Storage**
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

■ **General Use Guide**

- More than 1/100 dilution of 10mM of DMSO stock solution is essential

- For biomedical use to avoid DMSO concentration higher than 1%.

- Working concentrations for specific applications should be determined by the investigator.

- It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
- precipitated out from buffer solution.

■ **Data sheet PDF file**

CDg18 data sheet v0.2.pdf