This paper presents a deep learning-based approach for detecting mitotic figures, a key prognostic indicator in tumor pathology. Based on the state-of-the-art YOLOv12 object detection architecture, we developed an algorithm for the Mitosis DOmain Generalization (MIDOG) 2025 challenge. We achieved an F1-score of 0.7216 across complex and heterogeneous entire slide regions and ranked second on the final leaderboard.