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Enabling clinical use of foundation models for computational pathology

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Audun L Henriksen, Ole-Johan Skrede, Lisa van der Schee, Enric Domingo, Karolina Cyll, Sepp de Raedt, Ilya Kostolomov, Jennifer Hay, Wanja Kildal, Joakim Kalsnes, Robert W Williams, Manohar Pradhan, John Arne Nesheim, Hanne Askautrud, Maria Isaksen, Karmele Saez de Gordoa, Miriam Cuatrecasas, Joanne Edwards, TransSCOT group, Arild Nesbakken, Neil A Shepherd, Ian Tomlinson, Daniel-Christoph Wagner, Rachel Kerr, Tarjei Sveinsgjerd Hveem, Knut Liest{\o}l, Yoshiaki Nakamura, Marco Novelli, Masaaki Miyo, Sebastian Forsch, David N Church, Miangela M Lacle, David J Kerr, Andreas Kleppe

πŸ’‘ κ°œμš”

λ³Έ μ—°κ΅¬λŠ” 계산 병리학 λΆ„μ•Όμ—μ„œ νŒŒμš΄λ°μ΄μ…˜ λͺ¨λΈμ˜ μž„μƒ μ μš©μ„ κ°€λŠ₯ν•˜κ²Œ ν•˜λŠ” 방법을 μ œμ•ˆν•©λ‹ˆλ‹€. ν˜„μž¬ νŒŒμš΄λ°μ΄μ…˜ λͺ¨λΈμ΄ 생물학적 νŠΉμ§• 외에 μ „μ²˜λ¦¬ 및 μŠ€μΊλ„ˆ κ΄€λ ¨ 변이λ₯Ό ν¬μ°©ν•˜μ—¬ μ˜ˆμΈ‘μ— 편ν–₯을 μœ λ°œν•˜λŠ” 문제λ₯Ό ν•΄κ²°ν•˜κΈ° μœ„ν•΄, λ‹€μš΄μŠ€νŠΈλ¦Ό λͺ¨λΈ ν•™μŠ΅ μ‹œ μƒˆλ‘œμš΄ 강건성 손싀(robustness loss)을 λ„μž…ν–ˆμŠ΅λ‹ˆλ‹€. 이λ₯Ό 톡해 기술적 변이에 λŒ€ν•œ 민감도λ₯Ό 쀄이고 생물학적 νŠΉμ§•μ— μ§‘μ€‘ν•˜μ—¬ λΆ„λ₯˜ 정확도λ₯Ό ν–₯μƒμ‹œμΌ°μŠ΅λ‹ˆλ‹€.

πŸ”‘ μ‹œμ‚¬μ  및 ν•œκ³„

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νŒŒμš΄λ°μ΄μ…˜ λͺ¨λΈμ˜ 강건성 ν•œκ³„λ₯Ό μž¬ν•™μŠ΅ 없이 μ™„ν™”ν•˜μ—¬ μ‹€μ œ μž„μƒ ν™˜κ²½μ— λ”μš± μ ν•©ν•œ λͺ¨λΈ κ°œλ°œμ„ κ°€λŠ₯ν•˜κ²Œ ν•©λ‹ˆλ‹€.
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기술적 변이에 λŒ€ν•œ 민감도λ₯Ό κ°μ†Œμ‹œν‚€λ©΄μ„œλ„ 생물학적 νŠΉμ§•μ— μ§‘μ€‘ν•˜μ—¬ λ‹€μš΄μŠ€νŠΈλ¦Ό λͺ¨λΈμ˜ μ„±λŠ₯을 ν–₯μƒμ‹œν‚΅λ‹ˆλ‹€.
β€’
μ œμ‹œλœ λ°©λ²•λ‘ μ˜ μΌλ°˜ν™” κ°€λŠ₯μ„±κ³Ό λ‹€μ–‘ν•œ νŒŒμš΄λ°μ΄μ…˜ λͺ¨λΈ 및 μž„μƒ μ‹œλ‚˜λ¦¬μ˜€μ—μ„œμ˜ μ„±λŠ₯ 검증이 μΆ”κ°€μ μœΌλ‘œ ν•„μš”ν•©λ‹ˆλ‹€.
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