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High-Fidelity Synthetic ECG Generation via Mel-Spectrogram Informed Diffusion Training
Created by
Haebom
Author
Zhuoyi Huang, Nutan Sahoo, Anamika Kumari, Girish Kumar, Kexuan Cai, Shixing Cao, Yue Kang, Tian Xia, Somya Chatterjee, Nicholas Hausman, Aidan Jay, Eric S. Rosenthal, Soundar Srinivasan, Sadid Hasan, Alex Fedorov, Sulaiman Vesal
Outline
To address privacy concerns hindering the advancement of machine learning for cardiac management, this paper proposes a conditional diffusion-based Structured State Space Model (SSSD-ECG) capable of generating patient-specific physiological signals. To achieve this, we introduce Mel-Spectrogram Informed Diffusion Training (MIDT-ECG) with time-frequency domain supervision and multimodal demographic conditioning for patient-specific synthesis. We evaluate signal fidelity, clinical consistency, privacy, and downstream usability using the PTB-XL dataset. MIDT-ECG improves morphological consistency and enhances privacy, while enhancing signal-to-noise ratio and personalization capabilities through patient-specific synthesis.
Takeaways, Limitations
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Takeaways:
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Morphological consistency was improved by enhancing physiological structural realism through MIDT-ECG.
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We implemented patient-tailored synthesis by leveraging multimodal demographic conditions.
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It maintains strong privacy protection and shows 4-8% improvement in all indicators compared to existing methodologies.
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Even in low-data environments, classifiers trained with synthetic ECG data showed similar performance to classifiers trained with real data.
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We present advances for the responsible use of generative AI in healthcare.
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Limitations:
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There is no specific mention of Limitations in the paper. (There is no mention of Limitations in the paper summary information.)