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Adversarial Batch Representation Augmentation for Batch Correction in High-Content Cellular Screening

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Lei Tong, Xujing Yao, Adam Corrigan, Long Chen, Navin Rathna Kumar, Kerry Hallbrook, Jonathan Orme, Yinhai Wang, Huiyu Zhou

๐Ÿ’ก ๊ฐœ์š”

๋ณธ ๋…ผ๋ฌธ์€ ์„ธํฌ ์ด๋ฏธ์ง€ ๋ถ„์„์—์„œ ๋ฐœ์ƒํ•˜๋Š” ์‹คํ—˜ ์‹คํ–‰ ๊ฐ„ ๊ธฐ์ˆ ์  ์ฐจ์ด๋กœ ์ธํ•œ ์ƒ๋ฌผํ•™์  ๋ฐฐ์น˜ ํšจ๊ณผ(bio-batch effect) ๋ฌธ์ œ๋ฅผ ํ•ด๊ฒฐํ•˜๊ณ ์ž ํ•ฉ๋‹ˆ๋‹ค. ์ด๋ฅผ ์œ„ํ•ด ๋„๋ฉ”์ธ ์ผ๋ฐ˜ํ™”(Domain Generalization) ๊ด€์ ์—์„œ ์ ๋Œ€์  ๋ฐฐ์น˜ ํ‘œํ˜„ ์ฆ๊ฐ•(ABRA)์ด๋ผ๋Š” ์ƒˆ๋กœ์šด ๋ฐฉ๋ฒ•๋ก ์„ ์ œ์•ˆํ•ฉ๋‹ˆ๋‹ค. ABRA๋Š” ํ†ต๊ณ„์  ๋ณ€๋™์„ฑ์„ ๋ช…์‹œ์ ์œผ๋กœ ๋ชจ๋ธ๋งํ•˜๊ณ , ํ‘œํ˜„ ๊ณต๊ฐ„์—์„œ ์ตœ์•…์˜ ๋ฐฐ์น˜ ๊ต๋ž€์„ ์ ๊ทน์ ์œผ๋กœ ํ•ฉ์„ฑํ•˜์—ฌ ๋ฐฐ์น˜ ํšจ๊ณผ๋ฅผ ์™„ํ™”ํ•˜๋ฉฐ, ์ด๋ฅผ ํ†ตํ•ด siRNA ๊ต๋ž€ ๋ถ„๋ฅ˜์—์„œ ์ตœ๊ณ  ์„ฑ๋Šฅ์„ ๋‹ฌ์„ฑํ–ˆ์Šต๋‹ˆ๋‹ค.

๐Ÿ”‘ ์‹œ์‚ฌ์  ๋ฐ ํ•œ๊ณ„

โ€ข
๊ธฐ์กด ๋ฐฐ์น˜ ๋ณด์ • ๋ฐฉ๋ฒ•๋ก ์˜ ํ•œ๊ณ„๋ฅผ ๊ทน๋ณตํ•˜๊ณ , ์ถ”๊ฐ€์ ์ธ ์‚ฌ์ „ ์ง€์‹ ์—†์ด๋„ ํšจ๊ณผ์ ์ธ ๋ฐฐ์น˜ ํšจ๊ณผ ์™„ํ™”๊ฐ€ ๊ฐ€๋Šฅํ•จ์„ ์ž…์ฆํ–ˆ์Šต๋‹ˆ๋‹ค.
โ€ข
๋„๋ฉ”์ธ ์ผ๋ฐ˜ํ™” ํ”„๋ ˆ์ž„์›Œํฌ๋ฅผ ์ ์šฉํ•˜์—ฌ ๋‹ค์–‘ํ•œ ์‹คํ—˜ ์กฐ๊ฑด์—์„œ๋„ ๊ฐ•๊ฑดํ•œ ๋”ฅ๋Ÿฌ๋‹ ๋ชจ๋ธ ๊ตฌ์ถ• ๊ฐ€๋Šฅ์„ฑ์„ ์ œ์‹œํ–ˆ์Šต๋‹ˆ๋‹ค.
โ€ข
์ œ์•ˆ๋œ ABRA ๋ฐฉ๋ฒ•๋ก ์˜ ์‹ค์ œ ์ ์šฉ ๋ฒ”์œ„ ๋ฐ ๋‹ค์–‘ํ•œ ์œ ํ˜•์˜ ๋ฐฐ์น˜ ํšจ๊ณผ์— ๋Œ€ํ•œ ์ถ”๊ฐ€์ ์ธ ๊ฒ€์ฆ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.
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